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KMID : 0438219720090020183
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Korea University Medical Journal
1972 Volume.9 No. 2 p.183 ~ p.196
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An Experimental Study on Changes in Water Content and Electrolytes of the Uterus and liver Tissue in Castrated Rabbits by Administration of Cortisone for a Long Period of Time
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Abstract
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Author has attempted to clarify the effects of cortisone on electrolytes in the tissue of the uterus and liver tissue of of mature female rabbits weighing about 2kg.
Determination of electrolytes level of the uterus and liver tissue after administration of cortisone 25mg daily for 2 weeks after castration was undertaken.
The levels of Cl, Na, K, C, Mg and water contents in the organ tissue mentioned in the foregoing were determined and changes in electrolyte´s levels, and comparison of the electrolytes and water contents in these organ tissue were undertaken after a long term administration of cortisone in large doses on castrated rabbits.
Flame-photometry was utilized for the determination of Na and K levels, Schales and Schales method for Cl contents and Kovacs and Tarrnoky´s method for Ca and Mg contents.
The results obtained are summarized as follows:
1. Serum electrolyte´s levels of rabbits following castration produced no appreciable changes but a long term administration of cortisone in large doses to castrated female rabbits produced a decrease in Cl, K, Ca and Mg levels.
2. Castration of female rabbits produced a marked increase in Cl and Ca levels and marked decrease in Mg level of uterine tissue. A long term administration of cortisone in large doses to castrated female rabbits produced a marked increase in Cl, Na, Ca and Mg levels.
3. Castration of female rabbits produced an increase in Na, Mg levels and decrease in K level of the liver tissue. A long term administration of cortisone of large doses to the castrated female rabbits produced a marked decrease in Na, K, Ca levels and an increase in Mg level of the liver tissue.
4. Water content of the liver tissue of normal, castrated, and large doses of cortisone administered female rabbits showed a lower level as compared to that of the uterine tissue.
5. Cl content of the liver tissue showed markedly a lower level in comparison to that of the uterine tissue of normal, castrated and large doses of cortisone administered female rabbits.
6. Na content of the liver tissue showed a marked lower level in comparison to that of the uterine tissue of normal, castrated, and large dose of cortisone administered female rabbits.
7. K content of the liver tissue showed a marked lower level in comparison to that of the uterine tissue of normal, castrated, and large dose of cortisone administered female rabbits.
8. Ca content of the liver tissue showed a marked lower level in comparison to that of the uterine tissue of normal, castrated, and large dose of cortisone administered female rabbits.
9. Mg content of the liver tissue showed a lower level than that of the uterine tissue of normal, castrated, and large dose of cortisone administered female rabbits.
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